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Adcy5 Gene Detail  Symbol Name ID Adcy5 adenylate cyclase 5 MGI:99673 Nomenclature History Synonyms AC5 Genetic Map Chromosome 16 cytoband B-5   Mapping data( 2) Sequence Map Chr16:35154963-35305821 bp, + strand (From NCBI annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; dog, domestic; rat    (Mammalian Orthology) Protein SuperFamily: adenylate cyclase TreeFam: TF313845 Sequences Representative Sequences Length Strain/Species Flank genomic 224129 NCBI Gene Model | MGI Sequence Detail 150859 C57BL/6J ± Kb transcript NM_001012765 RefSeq | MGI Sequence Detail 5060 C57BL/6 polypeptide P84309 UniProt | EBI | MGI Sequence Detail 1262 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(19) Phenotypes All phenotypic alleles(2) : Targeted, knock-out(2) Targeted inactivation of this gene has been shown to result in motor dysfunction. Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)   Polymorphisms SNPs within 2kb(590 from dbSNP Build 128)   Gene Ontology (GO) classifications Process adenosine receptor signaling pathway, cAMP biosynthetic process... Component integral to membrane, membrane... Function adenylate cyclase activity, lyase activity... All GO classifications(20) Expression Literature Summary: (6 records) Data Summary: Assays (4)    Results (216)    Tissues (169)    Images (17) Theiler Stages: 22,23,28   Assay Type Assays   Results       RT-PCR 1   46       RNA in situ 3   170 cDNA source data(40) External Resources: Allen Brain Atlas  GEO  Pathways cyclic AMP biosynthesis Other database links EC 4.6.1.1 Ensembl Gene Model ENSMUSG00000022840 DoTS DT.55111830 UniGene 41137 DFCI TC1574016 NIA Mouse Gene Index U043517 Entrez Gene 224129 Protein domains InterPro ID Description IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase IPR009398 Adenylate cyclase-like Graphical View of Protein Domain Structure Molecular reagents All nucleic(45) cDNA(43) Primer pair(1) Other(1) References (Earliest) J:46603 Premont RT et al., "Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases." Proc Natl Acad Sci U S A 1992 Oct 15;89(20):9809-13 (Latest) J:140045 Kim KS et al., "Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior." J Neurochem 2008 Oct;107(1):105-15 All references(20) Other accession IDs MGD-MRK-16458, MGI:2146623