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Syk Gene Detail  Symbol Name ID Syk spleen tyrosine kinase MGI:99515 Nomenclature History Genetic Map Chromosome 13 37.0 cM, cytoband B-C2 Detailed Genetic Map ± 1 cM   Mapping data( 2) Sequence Map Chr13:52678542-52744161 bp, + strand (From VEGA annotation of NCBI Build 37) VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; pig, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Syk ± 2 cM) Protein SuperFamily: tyrosine-protein kinase, SYK/ZAP-70 type TreeFam: TF351629 Sequences Representative Sequences Length Strain/Species Flank genomic OTTMUSG00000031741 VEGA Gene Model | MGI Sequence Detail 65620 C57BL/6J ± Kb transcript NM_011518 RefSeq | MGI Sequence Detail 5148 C57BL/6 polypeptide P48025 UniProt | EBI | MGI Sequence Detail 629 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(28) Phenotypes All phenotypic alleles(4) : Targeted, knock-out(3) Targeted, other(1) Polymorphisms SNPs within 2kb(425 from dbSNP Build 128)   Gene Ontology (GO) classifications Process activation of JNK activity, activation of MAPK activity... Component B cell receptor complex, cytoplasm... Function ATP binding, kinase activity... All GO classifications(41) Expression Literature Summary: (7 records) Data Summary: Assays (5)    Results (12)    Tissues (2) Theiler Stages: 22,26   Assay Type Assays   Results       Western blot 5   12 cDNA source data(43) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links NIA Mouse Gene Index U014851 VEGA Gene Model OTTMUSG00000031741 Entrez Gene 20963 DoTS DT.101360528, DT.110965587, DT.489120, DT.91340731, DT.94124209 DFCI TC1588265, TC1672324 EC 2.7.10.2 Ensembl Gene Model ENSMUSG00000021457 UniGene 375031 Gene Traps OST221146, OST280409, OST62380 Protein domains InterPro ID Description IPR000719 Protein kinase, core IPR000980 SH2 motif IPR001245 Tyrosine protein kinase IPR008266 Tyrosine protein kinase, active site IPR012234 Tyrosine protein kinase, SYK/ZAP-70 IPR017441 Protein kinase ATP binding, conserved site Graphical View of Protein Domain Structure Molecular reagents All nucleic(44) Genomic(1) cDNA(43) Antibodies(5) References (Earliest) J:18037 Chan AC et al., "Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling." J Immunol 1994 May 15;152(10):4758-66 (Latest) J:140111 Zarbock A et al., "PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling." J Exp Med 2008 Sep 29;205(10):2339-47 All references(89) Other accession IDs MGD-MRK-16292