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Ltbp2 Gene Detail  Symbol Name ID Ltbp2 latent transforming growth factor beta binding protein 2 MGI:99502 Nomenclature History Genetic Map Chromosome 12 cytoband D   Mapping data( 3) Sequence Map Chr12:86124162-86217445 bp, - strand (From NCBI annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; rat    (Mammalian Orthology) Protein SuperFamily: latent transforming growth factor beta-binding protein TreeFam: TF317514 Sequences Representative Sequences Length Strain/Species Flank genomic 16997 NCBI Gene Model | MGI Sequence Detail 93284 C57BL/6J ± Kb transcript NM_013589 RefSeq | MGI Sequence Detail 6620 C57BL/6 polypeptide O08999 UniProt | EBI | MGI Sequence Detail 1813 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(12) Phenotypes All phenotypic alleles(1) : Targeted, knock-out(1) Mice homozygous for disruptions in this gene die as embryos sometime around the time of implantation. Polymorphisms SNPs within 2kb(547 from dbSNP Build 128)   Gene Ontology (GO) classifications Process metabolic process Component extracellular region Function binding, calcium ion binding... All GO classifications(6) Expression Literature Summary: (2 records) Data Summary: Assays (1)    Results (24)    Tissues (20) Theiler Stages: 24   Assay Type Assays   Results       RNA in situ 1   24 cDNA source data(24) External Resources: Allen Brain Atlas  GEO  Other database links Ensembl Gene Model ENSMUSG00000002020 UniGene 3900 DFCI TC1582227 Entrez Gene 16997 Protein domains InterPro ID Description IPR000152 EGF-type aspartate/asparagine hydroxylation conserved site IPR000742 EGF-like, type 3 IPR001881 EGF-like calcium-binding IPR002212 Matrix fibril-associated IPR006209 EGF-like IPR006210 EGF IPR013032 EGF-like region, conserved site IPR013091 EGF calcium-binding IPR013111 EGF, extracellular IPR016160 Aldehyde dehydrogenase, conserved site IPR017878 TGF-beta binding Graphical View of Protein Domain Structure Molecular reagents All nucleic(26) Genomic(1) cDNA(25) References (Earliest) J:37693 Nakajima Y et al., "Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart." J Cell Biol 1997 Jan 13;136(1):193-204 (Latest) J:97252 Rifkin DB, "Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability." J Biol Chem 2005 Mar 4;280(9):7409-12 All references(5) Other accession IDs MGD-MRK-16278, MGI:2145013