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Dsg3 Gene Detail  Symbol Name ID Dsg3 desmoglein 3 MGI:99499 Nomenclature History Genetic Map Chromosome 18 7.04 cM Detailed Genetic Map ± 1 cM   Mapping data( 13) Sequence Map Chr18:20668805-20699811 bp, + strand (From NCBI annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; dog, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Dsg3 ± 2 cM) Protein SuperFamily: cadherin TreeFam: TF331809 Sequences Representative Sequences Length Strain/Species Flank genomic 13512 NCBI Gene Model | MGI Sequence Detail 31007 C57BL/6J ± Kb transcript NM_030596 RefSeq | MGI Sequence Detail 4108 C57BL/6 polypeptide O35902 UniProt | EBI | MGI Sequence Detail 993 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(30) Phenotypes All phenotypic alleles(4) : Targeted, knock-out(1) Spontaneous(3) Homozygous mutants display runting from decreased food intake due to oropharyngeal epithelial lesions, blisters around snout and eyes, hair loss by weaning, and hair regrowth with bald patches throughout life. Associated Human Diseases (1)   Alleles Annotated to Human Diseases (3)   Phenotype Images (6)   Polymorphisms RFLP(1) SNPs within 2kb(147 from dbSNP Build 128)   Gene Ontology (GO) classifications Process cell adhesion, homophilic cell adhesion... Component cell junction, desmosome... Function calcium ion binding, protein binding... All GO classifications(13) Expression Literature Summary: (8 records) Data Summary: Assays (3)    Results (17)    Tissues (15)    Images (3) Theiler Stages: 10,18,23,25,28   Assay Type Assays   Results       Western blot 1   2       RT-PCR 1   13       Immunohistochemistry 1   2 cDNA source data(11) External Resources: Allen Brain Atlas  GEO  Other database links Ensembl Gene Model ENSMUSG00000056632 DoTS DT.87035019, DT.91445917 UniGene 106811 DFCI TC1589185, TC1595352 Entrez Gene 13512 Protein domains InterPro ID Description IPR002126 Cadherin IPR009122 Desmosomal cadherin IPR009123 Desmoglein Graphical View of Protein Domain Structure Molecular reagents All nucleic(13) Genomic(1) cDNA(11) Primer pair(1) Antibodies(1) References (Earliest) J:13702 Fox S et al., "Balding (bal)" Mouse News Lett 1977;56():40 (Latest) J:142136 Owens P et al., "Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity." Dev Biol 2008 Oct 1;322(1):156-66 All references(42) Other accession IDs MGD-MRK-1495, MGD-MRK-16273, MGI:88129