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Wnt7b Gene Detail  Symbol Name ID Wnt7b wingless-related MMTV integration site 7B MGI:98962 Nomenclature History Synonyms Wnt-7b Genetic Map Chromosome 15 46.9 cM Detailed Genetic Map ± 1 cM   Mapping data( 4) Sequence Map Chr15:85365877-85412012 bp, - strand (From Ensembl annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; dog, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Wnt7b ± 2 cM) Protein SuperFamily: int-1 transforming protein TreeFam: TF105310 Sequences Representative Sequences Length Strain/Species Flank genomic ENSMUSG00000022382 Ensembl Gene Model | MGI Sequence Detail 46136 C57BL/6J ± Kb transcript NM_009528 RefSeq | MGI Sequence Detail 3154 C57BL/6 polypeptide P28047 UniProt | EBI | MGI Sequence Detail 349 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(22) Phenotypes All phenotypic alleles(6) : Targeted, knock-out(2) Targeted, other(4) Homozygous null embryos die at midgestational stages due to placental abnormalities involving the fusion of the chorion and allantois. Mice homozygous for a truncated allele display neonatal lethality, respiratory failure, and lung hemorrhage. Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(176 from dbSNP Build 128)   Gene Ontology (GO) classifications Process cell-cell signaling, multicellular organismal development... Component extracellular region, proteinaceous extracellular matrix... Function protein binding, receptor binding... All GO classifications(16) Expression Literature Summary: (77 records) Data Summary: Assays (23)    Results (286)    Tissues (160)    Images (60) Theiler Stages: 1,2,3,4,5,8,9,11,13,15,16,17,19,20,21,22,23,24,26,28   Assay Type Assays   Results       Western blot 1   1       RT-PCR 6   30       RNA in situ 14   248       Immunohistochemistry 1   5       RNase protection 1   2 cDNA source data(54) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000022382 DoTS DT.101725892, DT.530872, DT.97386548 UniGene 306946 DFCI TC1580998, TC1597352, TC1602291 NIA Mouse Gene Index U036500 Entrez Gene 22422 Gene Traps OST147885 Protein domains InterPro ID Description IPR005816 Secreted growth factor Wnt protein IPR005817 Wnt superfamily IPR013300 Wnt-7 protein Graphical View of Protein Domain Structure Molecular reagents All nucleic(70) cDNA(58) Primer pair(8) Other(4) Antibodies(1) References (Earliest) J:10971 Gavin BJ et al., "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development." Genes Dev 1990 Dec;4(12B):2319-32 (Latest) J:139251 Lin C et al., "Tissue-specific requirements of beta-catenin in external genitalia development." Development 2008 Aug;135(16):2815-25 All references(97) Other accession IDs MGD-MRK-15447, MGD-MRK-15457