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Vcl Gene Detail  Symbol Name ID Vcl vinculin MGI:98927 Nomenclature History Synonyms metavinculin Genetic Map Chromosome 14 2.5 cM Detailed Genetic Map ± 1 cM   Mapping data( 3) Sequence Map Chr14:21748655-21852895 bp, + strand (From NCBI annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Vcl ± 2 cM) Protein SuperFamily: meta-vinculin TreeFam: TF313686 Sequences Representative Sequences Length Strain/Species Flank genomic 22330 NCBI Gene Model | MGI Sequence Detail 104241 C57BL/6J ± Kb transcript NM_009502 RefSeq | MGI Sequence Detail 5229 - polypeptide Q64727 UniProt | EBI | MGI Sequence Detail 1066 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(22) Phenotypes All phenotypic alleles(2) : Targeted, knock-out(1) Targeted, other(1) Homozygous null mutants die by embryonic day 10 with failed midline fusion of the rostral neural tube, bilobular cranial development and compromised cranial and spinal nerve development. Abnormal myocardial and endocardial structures are seen in the heart. Polymorphisms PCR(1) SNPs within 2kb(467 from dbSNP Build 128)   SNPs within 2kb including multiple locations(469) Gene Ontology (GO) classifications Process cell adhesion, lamellipodium assembly... Component actin cytoskeleton, adherens junction... Function actin binding, protein binding... All GO classifications(18) Expression Literature Summary: (19 records) Data Summary: Assays (5)    Results (104)    Tissues (48)    Images (4) Theiler Stages: 17,20,23,28   Assay Type Assays   Results       Western blot 3   12       RT-PCR 2   92 cDNA source data(137) External Resources: Allen Brain Atlas  GEO  Other database links Ensembl Gene Model ENSMUSG00000021823 UniGene 279361 DFCI TC1572867 NIA Mouse Gene Index U015370 Entrez Gene 22330 Gene Traps AA0327, AC0689, AN0225, CD0087, RRO431    (All 11...) Protein domains InterPro ID Description IPR000633 Vinculin, conserved site IPR006077 Vinculin/alpha-catenin Graphical View of Protein Domain Structure Molecular reagents All nucleic(140) Genomic(1) cDNA(137) Primer pair(2) Antibodies(3) References (Earliest) J:10655 Weller PA et al., "Complete sequence of human vinculin and assignment of the gene to chromosome 10." Proc Natl Acad Sci U S A 1990 Aug;87(15):5667-71 (Latest) J:137591 Lahmann I et al., "The hnRNP and cytoskeletal protein raver1 contributes to synaptic plasticity." Exp Cell Res 2008 Mar 10;314(5):1048-60 All references(37) Other accession IDs MGD-MRK-15386, MGI:2145572, MGI:2145658, MGI:2145826