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Stat5a Gene Detail  Symbol Name ID Stat5a signal transducer and activator of transcription 5A MGI:103036 Nomenclature History Synonyms STAT5 Genetic Map Chromosome 11 60.5 cM Detailed Genetic Map ± 1 cM   Mapping data( 6) Sequence Map Chr11:100720665-100746483 bp, + strand (From VEGA annotation of NCBI Build 37) VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; rat; sheep    (Mammalian Orthology) Comparative Map (Mouse/Human Stat5a ± 2 cM) Protein SuperFamily: signal transducer and transcription activator STAT5A TreeFam: TF318648 Sequences Representative Sequences Length Strain/Species Flank genomic OTTMUSG00000002125 VEGA Gene Model | MGI Sequence Detail 25819 C57BL/6J ± Kb transcript NM_011488 RefSeq | MGI Sequence Detail 3884 - polypeptide P42230 UniProt | EBI | MGI Sequence Detail 793 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(32) Phenotypes All phenotypic alleles(4) : Targeted, knock-out(3) Targeted, other(1) Mice homozygous for disruptions in this gene are reduced in size and display abnormalities in both mammary gland structure and function. Polymorphisms RFLP(1) SNPs within 2kb(78 from dbSNP Build 128)   SNPs within 2kb including multiple locations(86) Gene Ontology (GO) classifications Process 2-oxoglutarate metabolic process, allantoin metabolic process... Component cytoplasm, nucleus... Function calcium ion binding, DNA binding... All GO classifications(60) Expression Literature Summary: (12 records) Data Summary: Assays (4)    Results (77)    Tissues (74)    Images (3) Theiler Stages: 2,3,4,5,17,21,23,28   Assay Type Assays   Results       RT-PCR 2   61       RNA in situ 2   16 cDNA source data(65) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000004043 UniGene 277403 PDB 1Y1U NIA Mouse Gene Index U013347 Entrez Gene 20850 VEGA Gene Model OTTMUSG00000002125 Protein domains InterPro ID Description IPR000923 Blue (type 1) copper domain IPR000980 SH2 motif IPR001217 STAT transcription factor, core IPR011992 EF-Hand type IPR012345 STAT transcription factor, DNA-binding, subdomain IPR013799 STAT transcription factor, protein interaction IPR013800 STAT transcription factor, all-alpha IPR013801 STAT transcription factor, DNA-binding Graphical View of Protein Domain Structure Molecular reagents All nucleic(68) Genomic(1) cDNA(65) Primer pair(2) References (Earliest) J:24359 Mui AL et al., "Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs." EMBO J 1995 Mar 15;14(6):1166-75 (Latest) J:142128 Kerenyi MA et al., "Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1." Blood 2008 Nov 1;112(9):3878-88 All references(142) Other accession IDs MGD-MRK-23874, MGI:2144052