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Cacna1c Gene Detail  Symbol Name ID Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit MGI:103013 Nomenclature History Synonyms (alpha)1 subunit, Cav1.2, Cchl1a1, L-type Cav1.2 Genetic Map Chromosome 6 56.0 cM Detailed Genetic Map ± 1 cM   Mapping data( 3) Sequence Map Chr6:118543910-119146249 bp, - strand (From NCBI annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; dog, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Cacna1c ± 2 cM) Protein SuperFamily: voltage-gated calcium channel TreeFam: TF312805 Sequences Representative Sequences Length Strain/Species Flank genomic 12288 NCBI Gene Model | MGI Sequence Detail 602340 C57BL/6J ± Kb transcript NM_009781 RefSeq | MGI Sequence Detail 6510 - polypeptide Q01815 UniProt | EBI | MGI Sequence Detail 2139 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(26) Phenotypes All phenotypic alleles(5) : Targeted, knock-out(2) Targeted, other(3) Mice homozygous for mutations that inactivate the gene do not survive to term. Selective ablation in beta cells resulted in impaired insulin secretion and systemic glucose intolerance. Heterozygotes were hypozctive, showed increased anxiety, and poor motor coordination. Polymorphisms SNPs within 2kb(4155 from dbSNP Build 128)   Gene Ontology (GO) classifications Process adult walking behavior, calcium ion transport... Component caveolar macromolecular signaling complex, cell soma... Function calcium channel activity, calcium ion binding... All GO classifications(43) Expression Literature Summary: (12 records) Data Summary: Assays (12)    Results (205)    Tissues (113)    Images (88) Theiler Stages: 15,17,19,20,22,23,24,25,26,28   Assay Type Assays   Results       Immunohistochemistry 2   30       Northern blot 1   8       Western blot 1   2       RT-PCR 6   55       In situ reporter (knock in) 1   101       RNase protection 1   9 cDNA source data(25) External Resources: Allen Brain Atlas  GEO  Other database links Ensembl Gene Model ENSMUSG00000051331 DoTS DT.110472898, DT.526035, DT.91335512 UniGene 436656 DFCI TC1587639, TC1591466 NIA Mouse Gene Index U027794 Entrez Gene 12288 Gene Traps CMHD-GT_246C10-3, OST244748 Protein domains InterPro ID Description IPR002077 Voltage-dependent calcium channel, alpha-1 subunit IPR005446 Voltage-dependent calcium channel, L-type, alpha-1 subunit IPR005451 Voltage-dependent calcium channel, L-type, alpha-1C subunit IPR005821 Ion transport IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain Graphical View of Protein Domain Structure Molecular reagents All nucleic(33) Genomic(2) cDNA(26) Primer pair(5) Antibodies(4) References (Earliest) J:26177 Perez-Reyes E et al., "Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes." J Biol Chem 1990 Nov 25;265(33):20430-6 (Latest) J:140826 Essin K et al., "Indirect coupling between Cav1.2 channels and ryanodine receptors to generate Ca2+ sparks in murine arterial smooth muscle cells." J Physiol 2007 Oct 1;584(Pt 1):205-19 All references(50) Other accession IDs MGD-MRK-23850