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E2f4 Gene Detail  Symbol Name ID E2f4 E2F transcription factor 4 MGI:103012 Nomenclature History Synonyms 2010111M04Rik Genetic Map Chromosome 8 Syntenic   Mapping data( 2) Sequence Map Chr8:107821617-107829267 bp, + strand (From Ensembl annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; dog, domestic    (Mammalian Orthology) Protein SuperFamily: transcription factor E2F TreeFam: TF105566 Sequences Representative Sequences Length Strain/Species Flank genomic ENSMUSG00000014859 Ensembl Gene Model | MGI Sequence Detail 7651 C57BL/6J ± Kb transcript NM_148952 RefSeq | MGI Sequence Detail 2024 FVB/N polypeptide Q8R0K9 UniProt | EBI | MGI Sequence Detail 410 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(25) Phenotypes All phenotypic alleles(2) : Targeted, knock-out(2) Homozygous null mice die postnatally of an increased susceptibility to bacterial infection and exhibit craniofacial defects, erythroid abnormalities, and growth retardation. Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)   Polymorphisms SNPs within 2kb(10 from dbSNP Build 128)   Gene Ontology (GO) classifications Process blood circulation, cell cycle... Component cytoplasm, nucleus... Function DNA binding, protein binding... All GO classifications(22) Expression Literature Summary: (11 records) Data Summary: Assays (8)    Results (147)    Tissues (134)    Images (18) Theiler Stages: 2,3,4,5,15,17,19,20,21,22,24,26,28   Assay Type Assays   Results       Western blot 3   19       RT-PCR 2   25       RNA in situ 1   94       Northern blot 2   9 cDNA source data(63) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000014859 DoTS DT.101305806, DT.531602 UniGene 34554 DFCI TC1578435, TC1603667 NIA Mouse Gene Index U046903 Entrez Gene 104394 Gene Traps CC0783, CSA082, IST10808C8BBF1, IST10808C8HMF1, PST11447-NR    (All 13...) Protein domains InterPro ID Description IPR003316 Transcription factor E2F/dimerisation partner (TDP) IPR011991 Winged helix repressor DNA-binding IPR015633 E2F Family Graphical View of Protein Domain Structure Molecular reagents All nucleic(67) cDNA(63) Primer pair(3) Other(1) Antibodies(2) References (Earliest) J:21634 Beijersbergen RL et al., "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo." Genes Dev 1994 Nov 15;8(22):2680-90 (Latest) J:137644 Andrechek ER et al., "Patterns of cell signaling pathway activation that characterize mammary development." Development 2008 Jul;135(14):2403-13 All references(34) Other accession IDs MGD-MRK-23849, MGI:1919312, MGI:2142532