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Ccr7 Gene Detail  Symbol Name ID Ccr7 chemokine (C-C motif) receptor 7 MGI:103011 Nomenclature History Synonyms CD197, Cdw197, Cmkbr7, EBI1, Ebi1h Genetic Map Chromosome 11 cytoband D   Mapping data( 2) Sequence Map Chr11:99005510-99016391 bp, - strand (From VEGA annotation of NCBI Build 37) VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; dog, domestic; pig, domestic; rat    (Mammalian Orthology) Protein SuperFamily: chemokine receptor TreeFam: TF330966 Sequences Representative Sequences Length Strain/Species Flank genomic OTTMUSG00000006448 VEGA Gene Model | MGI Sequence Detail 10882 C57BL/6J ± Kb transcript NM_007719 RefSeq | MGI Sequence Detail 1975 C57BL/6 polypeptide P47774 UniProt | EBI | MGI Sequence Detail 378 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(21) Phenotypes All phenotypic alleles(2) : Targeted, knock-out(1) Targeted, other(1) Homozygous mice exhibit impairment of the primary immune response. Dendritic cells and B and T cells show impaired migration to the lymph nodes and secondary lymph organs exhibit morphological abnormalities. Lymphocytic infiltrates to the pancreas, lung and stomach are observed in aged mice. Polymorphisms SNPs within 2kb(29 from dbSNP Build 128)   Gene Ontology (GO) classifications Process chemotaxis, G-protein coupled receptor protein signaling pathway... Component integral to membrane, membrane... Function C-C chemokine receptor activity, G-protein coupled receptor activity... All GO classifications(13) Expression Literature Summary: (3 records) Data Summary: Assays (3)    Results (96)    Tissues (52)    Images (4) Theiler Stages: 26,28   Assay Type Assays   Results       RT-PCR 2   41       In situ reporter (knock in) 1   55 cDNA source data(18) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000037944 DoTS DT.530796 UniGene 2932 DFCI TC1580154 NIA Mouse Gene Index U033382 Entrez Gene 12775 VEGA Gene Model OTTMUSG00000006448 Protein domains InterPro ID Description IPR000276 GPCR, rhodopsin-like IPR000355 Chemokine receptor IPR001718 C-C chemokine receptor, type 7 IPR017452 GPCR, rhodopsin-like superfamily Graphical View of Protein Domain Structure Molecular reagents All nucleic(21) Genomic(1) cDNA(18) Primer pair(2) References (Earliest) J:21104 Schweickart VL et al., "Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2." Genomics 1994 Oct;23(3):643-50 (Latest) J:142197 Britschgi MR et al., "Dynamic modulation of CCR7 expression and function on naive T lymphocytes in vivo." J Immunol 2008 Dec 1;181(11):7681-8 All references(63) Other accession IDs MGD-MRK-23848