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Mtnr1a Gene Detail  Symbol Name ID Mtnr1a melatonin receptor 1A MGI:102967 Nomenclature History Synonyms Mel1a receptor, MelR Genetic Map Chromosome 8 25.0 cM Detailed Genetic Map ± 1 cM   Mapping data( 4) Sequence Map Chr8:46154564-46173860 bp, + strand (From NCBI annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; cattle; dog, domestic; pig, domestic; rat; sheep; hamster, golden    (Mammalian Orthology) Comparative Map (Mouse/Human Mtnr1a ± 2 cM) Protein SuperFamily: MT1-like melatonin receptor TreeFam: TF331693 Sequences Representative Sequences Length Strain/Species Flank genomic 17773 NCBI Gene Model | MGI Sequence Detail 19297 C57BL/6J ± Kb transcript NM_008639 RefSeq | MGI Sequence Detail 1503 - polypeptide Q61184 UniProt | EBI | MGI Sequence Detail 353 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(14) Phenotypes All phenotypic alleles(1) : Targeted, knock-out(1) Mice homozygous for disruptions in this gene are essentially normal, with normal circadian functions. In vitro studies report the absence of inhibitory effects of melatonin on suprachiasma neuronal firing. Polymorphisms SNPs within 2kb(204 from dbSNP Build 128)   Gene Ontology (GO) classifications Process circadian rhythm, G-protein coupled receptor protein signaling pathway... Component integral to membrane, membrane... Function G-protein coupled receptor activity, melatonin receptor activity... All GO classifications(12) Expression Literature Summary: (2 records) Data Summary: Assays (1)    Results (46)    Tissues (45)    Images (1) Theiler Stages: 23,28   Assay Type Assays   Results       RT-PCR 1   46 cDNA source data(2) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000054764 DoTS DT.101717581, DT.91326763 UniGene 5133 NIA Mouse Gene Index U156945 Entrez Gene 17773 Protein domains InterPro ID Description IPR000025 Melatonin receptor IPR000276 GPCR, rhodopsin-like IPR002278 Melatonin receptor type 1A IPR017452 GPCR, rhodopsin-like superfamily Graphical View of Protein Domain Structure Molecular reagents All nucleic(8) Genomic(4) cDNA(2) Primer pair(2) References (Earliest) J:26189 Slaugenhaupt SA et al., "Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)." Genomics 1995 May 20;27(2):355-7 (Latest) J:138555 Imbesi M et al., "Stimulatory effects of a melatonin receptor agonist, ramelteon, on BDNF in mouse cerebellar granule cells." Neurosci Lett 2008 Jul 4;439(1):34-6 All references(14) Other accession IDs MGD-MRK-23804