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Foxn1 Gene Detail  Symbol Name ID Foxn1 forkhead box N1 MGI:102949 Nomenclature History Synonyms D11Bhm185e, Hfh11, whn Genetic Map Chromosome 11 45.0 cM Detailed Genetic Map ± 1 cM   Mapping data( 23) Sequence Map Chr11:78171079-78200060 bp, - strand (From VEGA annotation of NCBI Build 37) VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; dog, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Foxn1 ± 2 cM) TreeFam: TF329867 Sequences Representative Sequences Length Strain/Species Flank genomic OTTMUSG00000000142 VEGA Gene Model | MGI Sequence Detail 28982 C57BL/6J ± Kb transcript NM_008238 RefSeq | MGI Sequence Detail 2503 BALB/c polypeptide Q61575 UniProt | EBI | MGI Sequence Detail 648 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(22) Phenotypes All phenotypic alleles(12) : Targeted, knock-out(1) Targeted, other(5) Spontaneous(6) Homozygotes for different mutations have in genetically determined absence or loss of hair and failed hair keratinization, premature lethality (differing by genetic background) and absence of thymus, resulting in multiple immune abnormalities. Heterozygotes have enlarged thymuses. Associated Human Diseases (1)   Alleles Annotated to Human Diseases (3)   Phenotype Images (4)   Polymorphisms PCR(3) SNPs within 2kb(18 from dbSNP Build 128)   Gene Ontology (GO) classifications Process epithelial cell proliferation, keratinocyte differentiation... Component nucleus Function DNA binding, sequence-specific DNA binding... All GO classifications(11) Expression Literature Summary: (22 records) Data Summary: Assays (8)    Results (49)    Tissues (28)    Images (13) Theiler Stages: 12,14,16,18,19,20,21,22,23,24,25,26,28   Assay Type Assays   Results       RT-PCR 3   29       RNA in situ 4   18       Northern blot 1   2 cDNA source data(8) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000002057 DoTS DT.524482 DFCI TC1589791, TC1712018, TC1725890 NIA Mouse Gene Index U033130 Entrez Gene 15218 VEGA Gene Model OTTMUSG00000000142 Gene Traps IST12393A6HMF1, OST428969, OST75988 Protein domains InterPro ID Description IPR001766 Fork head transcription factor IPR011991 Winged helix repressor DNA-binding Graphical View of Protein Domain Structure Molecular reagents All nucleic(32) Genomic(18) cDNA(8) Primer pair(4) Other(2) References (Earliest) J:2484 Truslove GM, "Genetical studies on the skeleton of the mouse. V. 'Interfrontal' and 'parted frontals'" J Genet 1952;51():115-122 (Latest) J:142181 Power KA et al., "Changes in biomarkers of estrogen receptor and growth factor signaling pathways in MCF-7 tumors after short- and long-term treatment with soy and flaxseed." J Steroid Biochem Mol Biol 2008 Nov;112(1-3):13-9 All references(312) Other accession IDs MGD-MRK-12946, MGD-MRK-23783, MGD-MRK-35270, MGI:106810