Search     All Search Tools Genes Genes & Markers Query Batch Query Maps & Mapping Data Mouse Genome Browser Mouse Linkage Map with Orthologs Cytogenetic Maps Physical Maps Mapping Data Query RI Strain Distribution Patterns RC Strain Distribution Patterns DNA Mapping Panel Data Sets More Phenotypes Phenotypes, Alleles & Diseases Query Mammalian Phenotype (MP) Browser Human Disease (OMIM) Browser More Expression Gene Expression Literature Query Gene Expression Data Query Gene Expression Data Expanded Query Mouse Anatomical Dictionary Browser EMAGE Anatomical Section Browser cDNA Clone Query More Function GO Browser Genes & Markers Query Batch Query More Pathways Strains / SNPs SNP Query RFLP/PCR Polymorphism Query Summary of SNP Data in MGI Inbred Strain Characteristics Genealogy Chart of Inbred Strains More Orthology Orthology Query Protein Superfamily (PIRSF) Browser Mouse Linkage Map with Orthologs Mouse-Human Orthology Map Mouse-Rat Orthology Map More Tumors Sequences Sequence Query Accession IDs Query MouseBLAST Protein Superfamily (PIRSF) Browser Mouse Genome Browser Batch Query Probes & Clones Molecular Probes and Clones Query cDNA Clones Query References Reference Query Gene Expression Literature Query Vocabularies GO Browser Human Disease (OMIM) Browser Mammalian Phenotype (MP) Browser Protein Superfamily (PIRSF) Browser Mouse Anatomical Dictionary Adult Mouse Anatomy Browser Accession IDs Query Batch Query MouseBLAST Mouse Genome Browser  Download     All MGI Reports Batch Query Genes & Markers Sequence Data Mammalian Orthology Gene Ontology Data Strains & Polymorphisms Gene Expression Phenotypic Data Nomenclature References Clone Collections  More Resources       More Resources Index Research Community E-mail Lists Online Books Biology of the Laboratory Mouse edited by Earl L. Green Mouse Genetics by Lee Silver The Anatomy of the Laboratory Mouse by Margaret J. Cook The Coat Colors of Mice by Willys K. Silvers Origins of Inbred Mice edited by Herbert C. Morse III Nomenclature Home Page MGI Glossary Prototype Tools Gene Expression Notebook (GEN) Mouse Phenome Database (MPD) Deltagen and Lexicon Knockout Mice International Knockout Mouse Consortium (IKMC) Knockout Mouse Project (KOMP, USA) European Conditional Mouse Mutagenesis (EUCOMM, Europe) North American Conditional Mouse Mutagenesis (NorCOMM, Canada) Texas Institute for Genomic Medicine (TIGM, USA) Trans-NIH Mouse Initiatives Contributed Data Sets Community Links Mouse Resources & Model Organism Links Phenotypes & Mutants Community Resources Mouse Facts Software Developer Tools Creating Web Links to MGI MGI Web Service Direct SQL Account Database Schema Browser All MGI Reports More Submit Data     Find Mice (IMSR)      Contact Us

Bdkrb2 Gene Detail  Symbol Name ID Bdkrb2 bradykinin receptor, beta 2 MGI:102845 Nomenclature History Synonyms B(2), B2, B2R, BK2R, kinin B2 Genetic Map Chromosome 12 53.0 cM Detailed Genetic Map ± 1 cM   Mapping data( 3) Sequence Map Chr12:106801382-106831281 bp, + strand (From NCBI annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; dog, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Bdkrb2 ± 2 cM) Protein SuperFamily: bradykinin receptor TreeFam: TF330024 Sequences Representative Sequences Length Strain/Species Flank genomic 12062 NCBI Gene Model | MGI Sequence Detail 29900 C57BL/6J ± Kb transcript NM_009747 RefSeq | MGI Sequence Detail 1680 - polypeptide P32299 UniProt | EBI | MGI Sequence Detail 392 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(16) Phenotypes All phenotypic alleles(2) : Targeted, knock-out(2) Homozygous null mutants are indistinguishable from normal littermates, but bradykinin response is eliminated in ileum, uterus, and cervical ganglia. Phenotype Images (1)   Polymorphisms RFLP(1) SNPs within 2kb(202 from dbSNP Build 128)   Gene Ontology (GO) classifications Process G-protein coupled receptor protein signaling pathway, signal transduction... Component integral to membrane, membrane... Function bradykinin receptor activity, G-protein coupled receptor activity... All GO classifications(11) Expression Literature Summary: (1 records) cDNA source data(9) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000021070 DoTS DT.87038645 UniGene 390475 DFCI TC1591564 NIA Mouse Gene Index U014344 Entrez Gene 12062 Gene Traps OST447596 Protein domains InterPro ID Description IPR000276 GPCR, rhodopsin-like IPR000496 Bradykinin receptor IPR001504 B2 bradykinin receptor IPR017452 GPCR, rhodopsin-like superfamily Graphical View of Protein Domain Structure Molecular reagents All nucleic(20) Genomic(10) cDNA(9) Other(1) References (Earliest) J:16469 McIntyre P et al., "Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity [published erratum appears in Mol Pharmacol 1994 Mar;45(3):561]" Mol Pharmacol 1993 Aug;44(2):346-55 (Latest) J:142529 Lu F et al., "The effect of C1 inhibitor on intestinal ischemia and reperfusion injury." Am J Physiol Gastrointest Liver Physiol 2008 Nov;295(5):G1042-9 All references(72) Other accession IDs MGD-MRK-19754