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Six1 Gene Detail  Symbol Name ID Six1 sine oculis-related homeobox 1 homolog (Drosophila) MGI:102780 Nomenclature History Genetic Map Chromosome 12 31.0 cM Detailed Genetic Map ± 1 cM   Mapping data( 3) Sequence Map Chr12:74142817-74147451 bp, - strand (From NCBI annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; dog, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Six1 ± 2 cM) TreeFam: TF315545 Sequences Representative Sequences Length Strain/Species Flank genomic 20471 NCBI Gene Model | MGI Sequence Detail 4635 C57BL/6J ± Kb transcript NM_009189 RefSeq | MGI Sequence Detail 2598 C57BL/6 polypeptide Q62231 UniProt | EBI | MGI Sequence Detail 284 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(16) Phenotypes All phenotypic alleles(4) : Targeted, knock-out(2) Targeted, other(2) Homozygotes for targeted null mutations exhibit rib defects, muscle hypoplasia, absence of kidneys and thymus, craniofacial defects, and ear and nose defects. Heterozygotes show partial hearing loss. Polymorphisms RFLP(1) SNPs within 2kb(14 from dbSNP Build 128)   Gene Ontology (GO) classifications Process anatomical structure development, embryonic skeletal system morphogenesis... Component nucleus, transcription factor complex... Function DNA binding, protein binding... All GO classifications(27) Expression Literature Summary: (29 records) Data Summary: Assays (11)    Results (142)    Tissues (103)    Images (62) Theiler Stages: 13,14,15,17,18,19,20,21,22,23,25,26,28   Assay Type Assays   Results       RT-PCR 1   2       In situ reporter (knock in) 3   20       RNA in situ 6   119       Northern blot 1   1 cDNA source data(6) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000051367 DoTS DT.101722109 DFCI TC1580234 NIA Mouse Gene Index U034063 Entrez Gene 20471 Gene Traps CMHD-GT_123D4-3, OST134064, OST141443, OST165262, OST167602    (All 18...) Protein domains InterPro ID Description IPR000047 Helix-turn-helix motif, lambda-like repressor IPR001356 Homeobox IPR012287 Homeodomain-related Graphical View of Protein Domain Structure Molecular reagents All nucleic(10) cDNA(7) Primer pair(1) Other(2) References (Earliest) J:23775 Oliver G et al., "Homeobox genes and connective tissue patterning." Development 1995 Mar;121(3):693-705 (Latest) J:131873 Depreux FF et al., "Eya4-deficient mice are a model for heritable otitis media." J Clin Invest 2008 Feb;118(2):651-8 All references(42) Other accession IDs MGD-MRK-19688, MGI:2145072