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Six3 Gene Detail  Symbol Name ID Six3 sine oculis-related homeobox 3 homolog (Drosophila) MGI:102764 Nomenclature History Genetic Map Chromosome 17 45.5 cM Detailed Genetic Map ± 1 cM   Mapping data( 2) Sequence Map Chr17:86020174-86023502 bp, + strand (From NCBI annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; dog, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Six3 ± 2 cM) TreeFam: TF315545 Sequences Representative Sequences Length Strain/Species Flank genomic 20473 NCBI Gene Model | MGI Sequence Detail 3329 C57BL/6J ± Kb transcript NM_011381 RefSeq | MGI Sequence Detail 1651 C57BL/6 polypeptide Q62233 UniProt | EBI | MGI Sequence Detail 333 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(20) Phenotypes All phenotypic alleles(6) : Targeted, knock-out(1) Targeted, other(5) Mice homozygous for disruptions of this gene die at birth with anterior structures of the head and brain undeveloped. Associated Human Diseases (1)   Alleles Annotated to Human Diseases (4)   Polymorphisms RFLP(1) SNPs within 2kb(4 from dbSNP Build 128)   Gene Ontology (GO) classifications Process brain development, camera-type eye development... Component nucleus Function DNA binding, protein binding... All GO classifications(23) Expression Literature Summary: (121 records) Data Summary: Assays (25)    Results (163)    Tissues (97)    Images (82) Theiler Stages: 9,11,12,13,14,15,17,19,20,21,22,24,26,28   Assay Type Assays   Results       RNA in situ 24   162       Northern blot 1   1 cDNA source data(8) External Resources: GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000038805 DFCI TC1586540, TC1594026, TC1596892, TC1696733 Entrez Gene 20473 Protein domains InterPro ID Description IPR000047 Helix-turn-helix motif, lambda-like repressor IPR001356 Homeobox IPR012287 Homeodomain-related Graphical View of Protein Domain Structure Molecular reagents All nucleic(15) cDNA(10) Other(5) References (Earliest) J:23775 Oliver G et al., "Homeobox genes and connective tissue patterning." Development 1995 Mar;121(3):693-705 (Latest) J:142425 Gaston-Massuet C et al., "Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development." Dev Biol 2008 Dec 15;324(2):322-33 All references(128) Other accession IDs MGD-MRK-19669