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Ednrb Gene Detail  Symbol Name ID Ednrb endothelin receptor type B MGI:102720 Nomenclature History Synonyms ETb, Sox10m1 Genetic Map Chromosome 14 51.0 cM Detailed Genetic Map ± 1 cM   Mapping data( 30) Sequence Map Chr14:104213843-104242913 bp, - strand (From NCBI annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; dog, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Ednrb ± 2 cM) Protein SuperFamily: endothelin receptor TreeFam: TF331292 Sequences Representative Sequences Length Strain/Species Flank genomic 13618 NCBI Gene Model | MGI Sequence Detail 29071 C57BL/6J ± Kb transcript NM_007904 RefSeq | MGI Sequence Detail 3989 C57BL/6 polypeptide P48302 UniProt | EBI | MGI Sequence Detail 442 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(70) Phenotypes All phenotypic alleles(38) : Targeted, knock-out(2) Targeted, other(6) Spontaneous(3) Chemically induced(12) Radiation induced(17) Homozygotes for null mutations have pigmentation limited to small patches on the head and rump, exhibit abnormal neural epithelium of the inner ear, and die from megacolon resulting from impaired neuronal migration and aganglia. Associated Human Diseases (3)   Alleles Annotated to Human Diseases (3)   Phenotype Images (8)   Polymorphisms All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(84 from dbSNP Build 128)   Gene Ontology (GO) classifications Process G-protein coupled receptor protein signaling pathway, melanocyte differentiation... Component integral to membrane, membrane... Function endothelin receptor activity, endothelin-B receptor activity... All GO classifications(22) Expression Literature Summary: (21 records) Data Summary: Assays (3)    Results (22)    Tissues (18) Theiler Stages: 18,23,25,26,28   Assay Type Assays   Results       RT-PCR 2   16       Northern blot 1   6 cDNA source data(124) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000022122 DoTS DT.101129975, DT.101212651, DT.40167075, DT.94152189, DT.94215927, DT.97408483 UniGene 229532 Entrez Gene 13618 Protein domains InterPro ID Description IPR000276 GPCR, rhodopsin-like IPR000499 Endothelin receptor IPR001112 Endothelin B receptor IPR017452 GPCR, rhodopsin-like superfamily Graphical View of Protein Domain Structure Molecular reagents All nucleic(127) Genomic(1) cDNA(124) Primer pair(2) References (Earliest) J:23183 Dunn LC, "Types of white spotting in mice" Am Naturalist 1920 Nov-Dec;54():465-95 (Latest) J:140320 Druckenbrod NR et al., "Targeting of endothelin receptor-B to the neural crest." Genesis 2008 Aug;46(8):396-400 All references(121) Other accession IDs MGD-MRK-14268, MGD-MRK-19624, MGI:2145744