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H2afx Gene Detail  Symbol Name ID H2afx H2A histone family, member X MGI:102688 Nomenclature History Synonyms H2A.X, H2ax, Hist5-2ax Genetic Map Chromosome 9 26.0 cM Detailed Genetic Map ± 1 cM   Mapping data( 6) Sequence Map Chr9:44142798-44144154 bp, + strand (From Ensembl annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; dog, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human H2afx ± 2 cM) Protein SuperFamily: histone H2A TreeFam: TF300137 Sequences Representative Sequences Length Strain/Species Flank genomic ENSMUSG00000049932 Ensembl Gene Model | MGI Sequence Detail 1357 C57BL/6J ± Kb transcript NM_010436 RefSeq | MGI Sequence Detail 1414 FVB/N polypeptide P27661 UniProt | EBI | MGI Sequence Detail 143 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(15) Phenotypes All phenotypic alleles(2) : Targeted, knock-out(2) Homozygous null mice are smaller and display increased susceptibility to ionizing radiation, male infertility, T and B cell abnormalities, and increased genomic instability. Polymorphisms SNPs within 2kb(45 from dbSNP Build 128)   Gene Ontology (GO) classifications Process cell cycle, DNA recombination... Component chromatin, chromosome... Function damaged DNA binding, DNA binding... All GO classifications(22) Expression Literature Summary: (16 records) Data Summary: Assays (2)    Results (27)    Tissues (23)    Images (25) Theiler Stages: 20,21,22,23,24,26,28   Assay Type Assays   Results       RNA in situ 1   14       Immunohistochemistry 1   13 cDNA source data(89) External Resources: Allen Brain Atlas  GEO  Other database links Ensembl Gene Model ENSMUSG00000049932 DoTS DT.101180324, DT.55282168 UniGene 245931 DFCI TC1575099 NIA Mouse Gene Index U010382 Entrez Gene 15270 Protein domains InterPro ID Description IPR002119 Histone H2A IPR007125 Histone core Graphical View of Protein Domain Structure Molecular reagents All nucleic(95) Genomic(3) cDNA(92) Antibodies(1) References (Earliest) J:11221 Nagata T et al., "Polyadenylated and 3' processed mRNAs are transcribed from the mouse histone H2A.X gene." Nucleic Acids Res 1991 May 11;19(9):2441-7 (Latest) J:142245 Lin Y et al., "Germ cell-intrinsic and -extrinsic factors govern meiotic initiation in mouse embryos." Science 2008 Dec 12;322(5908):1685-7 All references(53) Other accession IDs MGD-MRK-19571, MGD-MRK-19591, MGI:2143303