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Lhx3 Gene Detail  Symbol Name ID Lhx3 LIM homeobox protein 3 MGI:102673 Nomenclature History Synonyms Lim3, mLim-3, P-LIM Genetic Map Chromosome 2 16.0 cM, cytoband A2-C1 Detailed Genetic Map ± 1 cM   Mapping data( 5) Sequence Map Chr2:26055732-26063769 bp, - strand (From VEGA annotation of NCBI Build 37) VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; dog, domestic; pig, domestic; rat; guinea pig    (Mammalian Orthology) Comparative Map (Mouse/Human Lhx3 ± 2 cM) TreeFam: TF315442 Sequences Representative Sequences Length Strain/Species Flank genomic OTTMUSG00000012728 VEGA Gene Model | MGI Sequence Detail 8038 C57BL/6J ± Kb transcript NM_001039653 RefSeq | MGI Sequence Detail 2208 C57BL/6 polypeptide P50481 UniProt | EBI | MGI Sequence Detail 400 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(25) Phenotypes All phenotypic alleles(2) : Targeted, knock-out(1) Targeted, other(1) Homozygotes for a targeted null mutation exhibit failure of growth and differentiation of Rathke's pouch, lack both anterior and intermediate lobes of the pituitary gland, and die perinatally, within 24 hours of birth. Polymorphisms RFLP(1) SNPs within 2kb(48 from dbSNP Build 128)   Gene Ontology (GO) classifications Process cell differentiation, dorsal/ventral pattern formation... Component nucleus Function DNA binding, metal ion binding... All GO classifications(19) Expression Literature Summary: (77 records) Data Summary: Assays (14)    Results (189)    Tissues (136)    Images (39) Theiler Stages: 13,15,17,19,20,21,22,24,28   Assay Type Assays   Results       RNA in situ 10   177       Immunohistochemistry 4   12 cDNA source data(17) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000026934 UniGene 386765 PDB 2JTN DFCI TC1583743, TC1594343, TC1596887 NIA Mouse Gene Index U022415 Entrez Gene 16871 VEGA Gene Model OTTMUSG00000012728 Protein domains InterPro ID Description IPR001356 Homeobox IPR001781 Zinc finger, LIM-type IPR012287 Homeodomain-related Graphical View of Protein Domain Structure Molecular reagents All nucleic(27) Genomic(4) cDNA(19) Primer pair(1) Other(3) Antibodies(3) References (Earliest) J:22277 Seidah NG et al., "The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary." DNA Cell Biol 1994 Dec;13(12):1163-80 (Latest) J:142425 Gaston-Massuet C et al., "Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development." Dev Biol 2008 Dec 15;324(2):322-33 All references(96) Other accession IDs MGD-MRK-19576