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Pou4f1 Gene Detail  Symbol Name ID Pou4f1 POU domain, class 4, transcription factor 1 MGI:102525 Nomenclature History Synonyms Brn-3, Brn-3.0, Brn3, Brn3a, E130119J07Rik Genetic Map Chromosome 14 cytoband E1-E3   Mapping data( 4) Sequence Map Chr14:104861550-104867216 bp, - strand (From Ensembl annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; rat    (Mammalian Orthology) Protein SuperFamily: POU domain class 4 transcription factor, Brn3 type TreeFam: TF316413 Sequences Representative Sequences Length Strain/Species Flank genomic ENSMUSG00000048349 Ensembl Gene Model | MGI Sequence Detail 5667 C57BL/6J ± Kb transcript NM_011143 RefSeq | MGI Sequence Detail 3801 - polypeptide P17208 UniProt | EBI | MGI Sequence Detail 421 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(25) Phenotypes All phenotypic alleles(5) : Targeted, knock-out(4) Targeted, other(1) Mice homozygous for disruptions in this gene die within the first day after birth and display various abnormalities in the brain and cranial nerves. Phenotype Images (6)   Polymorphisms RFLP(1) SNPs within 2kb(32 from dbSNP Build 128)   Gene Ontology (GO) classifications Process cell migration in hindbrain, central nervous system neuron differentiation... Component nucleus Function DNA binding, protein binding... All GO classifications(21) Expression Literature Summary: (91 records) Data Summary: Assays (26)    Results (160)    Tissues (80)    Images (36) Theiler Stages: 15,16,17,18,19,20,21,22,23,24,25,26,28   Assay Type Assays   Results       RT-PCR 10   42       RNA in situ 5   49       Immunohistochemistry 5   30       Northern blot 3   3       RNase protection 3   36 cDNA source data(11) External Resources: Allen Brain Atlas  GEO  Other database links Ensembl Gene Model ENSMUSG00000048349 DoTS DT.101294043, DT.97354483 DFCI TC1587821, TC1605341, TC1620170 Entrez Gene 18996 Gene Traps XT0546 Protein domains InterPro ID Description IPR000327 POU-specific IPR001356 Homeobox IPR012287 Homeodomain-related IPR013847 POU IPR015584 POU domain class 4 related Graphical View of Protein Domain Structure Molecular reagents All nucleic(30) Genomic(9) cDNA(12) Primer pair(5) Other(4) Antibodies(2) References (Earliest) J:9856 He X et al., "Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]" Nature 1989 Jul 6;340(6228):35-41 (Latest) J:142507 Tian NM et al., "Foxg1 regulates retinal axon pathfinding by repressing an ipsilateral program in nasal retina and by causing optic chiasm cells to exert a net axonal growth-promoting activity." Development 2008 Dec;135(24):4081-9 All references(114) Other accession IDs MGD-MRK-1625, MGD-MRK-1629, MGD-MRK-1630, MGD-MRK-19369, MGI:1925256