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Cacnb1 Gene Detail  Symbol Name ID Cacnb1 calcium channel, voltage-dependent, beta 1 subunit MGI:102522 Nomenclature History Synonyms Cchb1, Cchlb1 Genetic Map Chromosome 11 58.0 cM Detailed Genetic Map ± 1 cM   Mapping data( 4) Sequence Map Chr11:97862822-97884348 bp, - strand (From VEGA annotation of NCBI Build 37) VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; dog, domestic; rabbit, European; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Cacnb1 ± 2 cM) Protein SuperFamily: human voltage-dependent calcium channel beta chain TreeFam: TF316195 Sequences Representative Sequences Length Strain/Species Flank genomic OTTMUSG00000002912 VEGA Gene Model | MGI Sequence Detail 21527 C57BL/6J ± Kb transcript NM_031173 RefSeq | MGI Sequence Detail 1892 - polypeptide Q8R3Z5 UniProt | EBI | MGI Sequence Detail 597 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(33) Phenotypes All phenotypic alleles(1) : Targeted, knock-out(1) Homozygous mutation of this gene results in perinatal lethality. Mutant animals have reduced muscle mass, thin limbs, a curved spine, and flexed necks and extremeties. Phenotype Images (1)   Polymorphisms RFLP(2) SNPs within 2kb(103 from dbSNP Build 128)   Gene Ontology (GO) classifications Process calcium ion transport, ion transport... Component membrane, plasma membrane... Function calcium channel activity, calcium ion binding... All GO classifications(18) Expression Literature Summary: (2 records) Data Summary: Assays (1)    Results (3)    Tissues (2) Theiler Stages: 25,28   Assay Type Assays   Results       RT-PCR 1   3 cDNA source data(3) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000020882 DoTS DT.101259077, DT.101371944, DT.101371945, DT.40181792 DFCI TC1584319, TC1593619, TC1607224, TC1630903 NIA Mouse Gene Index U033356 Entrez Gene 12295 VEGA Gene Model OTTMUSG00000002912 Gene Traps OST168345, OST19535, OST2802, RRD139 Protein domains InterPro ID Description IPR000584 Voltage-dependent calcium channel, L-type, beta subunit IPR001452 Src homology-3 domain IPR005443 Voltage-dependent calcium channel, L-type, beta-1 subunit IPR008145 Guanylate kinase/L-type calcium channel region Graphical View of Protein Domain Structure Molecular reagents All nucleic(7) Genomic(1) cDNA(5) Primer pair(1) References (Earliest) J:28890 Ruth P et al., "Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle." Science 1989 Sep 8;245(4922):1115-8 (Latest) J:119550 Harrell MD et al., "Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development." Physiol Genomics 2007 Feb 12;28(3):273-83 All references(18) Other accession IDs MGD-MRK-1802, MGD-MRK-19366