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Mlh1 Gene Detail  Symbol Name ID Mlh1 mutL homolog 1 (E. coli) MGI:101938 Nomenclature History Synonyms 1110035C23Rik, colon cancer, nonpolyposis type 2 Genetic Map Chromosome 9 62.0 cM Detailed Genetic Map ± 1 cM   Mapping data( 2) Sequence Map Chr9:111130732-111174112 bp, - strand (From VEGA annotation of NCBI Build 37) VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; dog, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Mlh1 ± 2 cM) Protein SuperFamily: DNA mismatch repair protein, Mlh1 type TreeFam: TF300493 Sequences Representative Sequences Length Strain/Species Flank genomic OTTMUSG00000031784 VEGA Gene Model | MGI Sequence Detail 43381 C57BL/6J ± Kb transcript NM_026810 RefSeq | MGI Sequence Detail 2548 CZECHII polypeptide Q9JK91 UniProt | EBI | MGI Sequence Detail 760 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(35) Phenotypes All phenotypic alleles(4) : Targeted, knock-out(3) Targeted, other(1) Homozygotes for targeted null mutations exhibit reduced pairing in meiotic prophase I and produce no mature germ cells. Mutants also display increased microsatellite instability and a predisposition for developing intestinal and other tumors. Phenotype Images (1)   Polymorphisms SNPs within 2kb(278 from dbSNP Build 128)   Gene Ontology (GO) classifications Process cell cycle, DNA damage response, signal transduction resulting in induction of apoptosis... Component chiasma, chromosome... Function ATP binding, guanine/thymine mispair binding... All GO classifications(46) Expression Literature Summary: (7 records) Data Summary: Assays (1)    Results (2)    Tissues (1)    Images (1) Theiler Stages: 28   Assay Type Assays   Results       RT-PCR 1   2 cDNA source data(56) External Resources: Allen Brain Atlas  GEO  Other database links Ensembl Gene Model ENSMUSG00000032498 DoTS DT.101140778, DT.490690, DT.94219805, DT.99850998 UniGene 196006 DFCI TC1577324, TC1594658, TC1672190 NIA Mouse Gene Index U031377 Entrez Gene 17350 VEGA Gene Model OTTMUSG00000031784 Gene Traps AD0694, CMHD-GT_252C9-3, OST181272, OST234108, OST312756    (All 6...) Protein domains InterPro ID Description IPR002099 DNA mismatch repair protein IPR003594 ATP-binding region, ATPase-like IPR011186 DNA mismatch repair protein Mlh1 IPR013507 DNA mismatch repair protein, C-terminal IPR014721 Ribosomal protein S5 domain 2-type fold IPR014762 DNA mismatch repair, conserved site IPR014763 DNA mismatch repair protein, N-terminal Graphical View of Protein Domain Structure Molecular reagents All nucleic(57) cDNA(56) Primer pair(1) References (Earliest) J:17196 Bronner CE et al., "Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer." Nature 1994 Mar 17;368(6468):258-61 (Latest) J:139050 Frumkin D et al., "Cell lineage analysis of a mouse tumor." Cancer Res 2008 Jul 15;68(14):5924-31 All references(75) Other accession IDs MGD-MRK-18771, MGI:1915937, MGI:2143018, MGI:2143023, MGI:2143094