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Cpe Gene Detail  Symbol Name ID Cpe carboxypeptidase E MGI:101932 Nomenclature History Synonyms carboxypeptidase H, CPH, Cph-1, Cph1 Genetic Map Chromosome 8 32.6 cM Detailed Genetic Map ± 1 cM   Mapping data( 20) Sequence Map Chr8:67071355-67171837 bp, - strand (From Ensembl annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Cpe ± 2 cM) Protein SuperFamily: carboxypeptidase, M type TreeFam: TF315592 Sequences Representative Sequences Length Strain/Species Flank genomic ENSMUSG00000037852 Ensembl Gene Model | MGI Sequence Detail 100483 C57BL/6J ± Kb transcript NM_013494 RefSeq | MGI Sequence Detail 2103 - polypeptide Q00493 UniProt | EBI | MGI Sequence Detail 476 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(46) Phenotypes All phenotypic alleles(2) : Targeted, knock-out(1) Spontaneous(1) Mice homozygous for a spontaneous or a targeted null mutation display progressive obesity, abnormal blood glucose and lipid regulation, and have reduced fertility. Aberrant prohormone processing and secretion appears to be the cause of these phenotypes. Polymorphisms All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(801 from dbSNP Build 128)   Gene Ontology (GO) classifications Process insulin processing, proteolysis... Component extracellular region Function carboxypeptidase activity, hydrolase activity... All GO classifications(11) Expression Literature Summary: (6 records) Data Summary: Assays (3)    Results (112)    Tissues (107)    Images (27) Theiler Stages: 21,22,24,25,28   Assay Type Assays   Results       RNA in situ 3   112 cDNA source data(7) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links EC 3.4.17.10 Ensembl Gene Model ENSMUSG00000037852 DoTS DT.103573378, DT.110891014, DT.535307 DFCI TC1573276 NIA Mouse Gene Index U029872 Entrez Gene 12876 Gene Traps CMHD-GT_264E12-3, CMHD-GT_268F7-3, CMHD-GT_524F9-3, IST11243B3BBF1, IST11370C8HMF2 Protein domains InterPro ID Description IPR000834 Peptidase M14, carboxypeptidase A IPR014766 Carboxypeptidase, regulatory region Graphical View of Protein Domain Structure Molecular reagents All nucleic(15) Genomic(1) cDNA(10) Primer pair(3) Other(1) References (Earliest) J:13651 Hummel KP et al., "fat = fat, Chr UN." Mouse News Lett 1974;50():43 (Latest) J:138523 Wang F et al., "Transcription factor PU.1 is expressed in white adipose and inhibits adipocyte differentiation." Am J Physiol Cell Physiol 2008 Jul;295(1):C213-20 All references(79) Other accession IDs MGD-MRK-18763, MGD-MRK-2106, MGD-MRK-2107, MGD-MRK-9713, MGI:2142890