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Dlx6 Gene Detail  Symbol Name ID Dlx6 distal-less homeobox 6 MGI:101927 Nomenclature History Genetic Map Chromosome 6 2.0 cM Detailed Genetic Map ± 1 cM   Mapping data( 3) Sequence Map Chr6:6813750-6817329 bp, + strand (From Ensembl annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human    (Mammalian Orthology) Comparative Map (Mouse/Human Dlx6 ± 2 cM) TreeFam: TF315720 Sequences Representative Sequences Length Strain/Species Flank genomic ENSMUSG00000029754 Ensembl Gene Model | MGI Sequence Detail 3580 C57BL/6J ± Kb transcript NM_010057 RefSeq | MGI Sequence Detail 978 C57BL/6 polypeptide P70397 UniProt | EBI | MGI Sequence Detail 175 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(20) Phenotypes All phenotypic alleles(3) : Targeted, other(3) Homozygotes for targeted null mutations at both Dlx5 and Dlx6 exhibit bilateral ectrodactyly, homeotic transformation of the lower jaw into an upper jaw, and perinatal lethality. Associated Human Diseases (1)   Alleles Annotated to Human Diseases (2)   Polymorphisms SNPs within 2kb(15 from dbSNP Build 128)   Gene Ontology (GO) classifications Process anatomical structure formation, embryonic limb morphogenesis... Component nucleus Function DNA binding, sequence-specific DNA binding... All GO classifications(14) Expression Literature Summary: (46 records) Data Summary: Assays (10)    Results (167)    Tissues (148)    Images (36) Theiler Stages: 15,17,19,20,21,22,23,24,28   Assay Type Assays   Results       RNA in situ 8   155       Immunohistochemistry 2   12 cDNA source data(5) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000029754 DoTS DT.94272934 DFCI TC1649605 NIA Mouse Gene Index U006522 Entrez Gene 13396 Protein domains InterPro ID Description IPR000047 Helix-turn-helix motif, lambda-like repressor IPR001356 Homeobox IPR012287 Homeodomain-related Graphical View of Protein Domain Structure Molecular reagents All nucleic(13) Genomic(2) cDNA(8) Primer pair(1) Other(2) Antibodies(1) References (Earliest) J:17176 Simeone A et al., "Cloning and characterization of two members of the vertebrate Dlx gene family." Proc Natl Acad Sci U S A 1994 Mar 15;91(6):2250-4 (Latest) J:139700 Jeong J et al., "Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs." Development 2008 Sep;135(17):2905-16 All references(54) Other accession IDs MGD-MRK-18758