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Calb2 Gene Detail  Symbol Name ID Calb2 calbindin 2 MGI:101914 Nomenclature History Synonyms calretinin, CR Genetic Map Chromosome 8 Syntenic   Mapping data( 2) Sequence Map Chr8:112666439-112692106 bp, - strand (From Ensembl annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; dog, domestic; rat    (Mammalian Orthology) Protein SuperFamily: calretinin TreeFam: TF325083 Sequences Representative Sequences Length Strain/Species Flank genomic ENSMUSG00000003657 Ensembl Gene Model | MGI Sequence Detail 25668 C57BL/6J ± Kb transcript NM_007586 RefSeq | MGI Sequence Detail 1462 - polypeptide Q08331 UniProt | EBI | MGI Sequence Detail 271 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(13) Phenotypes All phenotypic alleles(1) : Targeted, knock-out(1) Homozygous targeted mutants showed normal growth, normal brain histology, and generally normal behavior. Impaired motor coordination was observed in wheel running in young and old mutant mice, and progressive impairment was seen on the runway and horizontal stationary rod tests in older mice. Abnormalities are observed in Purkinje cell firing, altering both simple and complex spikes. Polymorphisms SNPs within 2kb(121 from dbSNP Build 128)   Gene Ontology (GO) classifications Component gap junction Function calcium ion binding All GO classifications(3) Expression Literature Summary: (205 records) Data Summary: Assays (15)    Results (254)    Tissues (157)    Images (34) Theiler Stages: 19,21,22,23,24,25,26,28   Assay Type Assays   Results       RNA in situ 2   163       Immunohistochemistry 12   45       RT-PCR 1   46 cDNA source data(37) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000003657 DoTS DT.40164012 UniGene 2755 DFCI TC1576082 NIA Mouse Gene Index U030243 Entrez Gene 12308 Protein domains InterPro ID Description IPR002048 Calcium-binding EF-hand IPR011992 EF-Hand type Graphical View of Protein Domain Structure Molecular reagents All nucleic(42) Genomic(2) cDNA(38) Primer pair(2) Antibodies(11) References (Earliest) J:17458 Ninomiya T et al., "Mouse fetal trisomy 13 and hypotrophy of the spinal cord: effect on calbindin-D28k and calretinin expressed by neurons of the spinal cord and dorsal root ganglia." Neuroscience 1993 Dec;57(4):1109-20 (Latest) J:142365 Barry G et al., "Specific glial populations regulate hippocampal morphogenesis." J Neurosci 2008 Nov 19;28(47):12328-40 All references(225) Other accession IDs MGD-MRK-18743