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Mmp14 Gene Detail  Symbol Name ID Mmp14 matrix metallopeptidase 14 (membrane-inserted) MGI:101900 Nomenclature History Synonyms Membrane type 1-MMP, MT1-MMP Genetic Map Chromosome 14 12.5 cM Detailed Genetic Map ± 1 cM   Mapping data( 6) Sequence Map Chr14:55050456-55060090 bp, + strand (From NCBI annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Mmp14 ± 2 cM) Protein SuperFamily: matrix metalloproteinase, stromelysin type TreeFam: TF315428 Sequences Representative Sequences Length Strain/Species Flank genomic 17387 NCBI Gene Model | MGI Sequence Detail 9635 C57BL/6J ± Kb transcript NM_008608 RefSeq | MGI Sequence Detail 2597 C57BL/6 polypeptide P53690 UniProt | EBI | MGI Sequence Detail 582 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(60) Phenotypes All phenotypic alleles(6) : Targeted, knock-out(4) Targeted, other(1) Chemically induced(1) Homozygous null mice exhibit craniofacial dysmorphism, arthritis, osteopenia, dwarfism, fibrosis of soft tissue, reduced bone formation, pulmonary hypoplasia, and impaired alveologenesis. Associated Human Diseases (2)   Alleles Annotated to Human Diseases (1)   Phenotype Images (1)   Polymorphisms PCR(1) SNPs within 2kb(46 from dbSNP Build 128)   Gene Ontology (GO) classifications Process branching morphogenesis of a tube, cell migration... Component integral to membrane, membrane... Function calcium ion binding, hydrolase activity... All GO classifications(19) Expression Literature Summary: (23 records) Data Summary: Assays (4)    Results (10)    Tissues (7)    Images (5) Theiler Stages: 17,19,22,23,28   Assay Type Assays   Results       RT-PCR 3   7       RNA in situ 1   3 cDNA source data(208) External Resources: Allen Brain Atlas  GEO  Other database links EC 3.4.24.80 Ensembl Gene Model ENSMUSG00000000957 DoTS DT.87072804 UniGene 280175 DFCI TC1572262 NIA Mouse Gene Index U015622 Entrez Gene 17387 Gene Traps IST10074C9BBF1, IST10074C9BBR1, IST10285F5HMF1, IST12354B1BBF1, IST12354B1HMF1    (All 7...) Protein domains InterPro ID Description IPR000585 Hemopexin IPR001818 Peptidase M10A and M12B, matrixin and adamalysin IPR002477 Peptidoglycan binding-like IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site IPR006026 Peptidase, metallopeptidases IPR016293 Peptidase M10A, matrix metallopeotidase Graphical View of Protein Domain Structure Molecular reagents All nucleic(215) Genomic(2) cDNA(209) Primer pair(3) Other(1) References (Earliest) J:22683 Sato H et al., "A matrix metalloproteinase expressed on the surface of invasive tumour cells [see comments]" Nature 1994 Jul 7;370(6484):61-5 (Latest) J:142651 Azar DT et al., "Effect of MT1-MMP deficiency and overexpression in corneal keratocytes on vascular endothelial cell migration and proliferation." Curr Eye Res 2008 Nov;33(11):954-62 All references(65) Other accession IDs MGD-MRK-18727, MGI:2145621