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Pou3f2 Gene Detail  Symbol Name ID Pou3f2 POU domain, class 3, transcription factor 2 MGI:101895 Nomenclature History STS D4Mit171 Synonyms 9430075J19Rik, A230098E07Rik, Brn-2, Brn2, Otf7 Genetic Map Chromosome 4 6.3 cM Detailed Genetic Map ± 1 cM   Mapping data( 5) Sequence Map Chr4:22413791-22415480 bp, - strand (From VEGA annotation of NCBI Build 37) VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; dog, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Pou3f2 ± 2 cM) Protein SuperFamily: POU domain class 3 transcription factor, brain type TreeFam: TF316413 Sequences Representative Sequences Length Strain/Species Flank genomic OTTMUSG00000004749 VEGA Gene Model | MGI Sequence Detail 1690 C57BL/6J ± Kb transcript NM_008899 RefSeq | MGI Sequence Detail 1338 BALB/c polypeptide P31360 UniProt | EBI | MGI Sequence Detail 445 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(27) Phenotypes All phenotypic alleles(2) : Targeted, knock-out(2) Homozygous mutation of this gene results in lethality by 10 days of age. Mutant animals are growth retarded, have hyperkeratotic, flaky skin, and exhibit loss of the posterior pituitary and disruption of late endocrine hypothalamic development. Polymorphisms RFLP(1) Gene Ontology (GO) classifications Process astrocyte development, cerebral cortex radially oriented cell migration... Component nucleus, transcription factor complex... Function DNA binding, sequence-specific DNA binding... All GO classifications(24) Expression Literature Summary: (32 records) Data Summary: Assays (4)    Results (56)    Tissues (44)    Images (21) Theiler Stages: 13,17,18,19,20,21,23,28   Assay Type Assays   Results       RNA in situ 4   56 cDNA source data(12) External Resources: GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000052621, ENSMUSG00000073984 DoTS DT.101300997, DT.101344831, DT.87071029 DFCI TC1598671, TC1598925, TC1646000 NIA Mouse Gene Index U024883 Entrez Gene 18992 VEGA Gene Model OTTMUSG00000004749 Protein domains InterPro ID Description IPR000327 POU-specific IPR001356 Homeobox IPR012287 Homeodomain-related IPR013847 POU IPR016362 Transcription factor, homeobox/POU Graphical View of Protein Domain Structure Molecular reagents All nucleic(20) Genomic(3) cDNA(14) Primer pair(2) Other(1) References (Earliest) J:9856 He X et al., "Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]" Nature 1989 Jul 6;340(6228):35-41 (Latest) J:139601 Sunabori T et al., "Cell-cycle-specific nestin expression coordinates with morphological changes in embryonic cortical neural progenitors." J Cell Sci 2008 Apr 15;121(Pt 8):1204-12 All references(47) Other accession IDs MGD-MRK-13082, MGD-MRK-1624, MGD-MRK-1628, MGD-MRK-18722, MGI:1924614, MGI:2443081