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Pou3f4 Gene Detail  Symbol Name ID Pou3f4 POU domain, class 3, transcription factor 4 MGI:101894 Nomenclature History Synonyms BRN-4, Brn4, Otf9 Genetic Map Chromosome X 48.4 cM Detailed Genetic Map ± 1 cM   Mapping data( 9) Sequence Map ChrX:108009761-108012545 bp, + strand (From VEGA annotation of NCBI Build 37) VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; dog, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Pou3f4 ± 2 cM) Protein SuperFamily: POU domain class 3 transcription factor, brain type TreeFam: TF316413 Sequences Representative Sequences Length Strain/Species Flank genomic OTTMUSG00000018379 VEGA Gene Model | MGI Sequence Detail 2785 C57BL/6J ± Kb transcript NM_008901 RefSeq | MGI Sequence Detail 1086 BALB/c polypeptide P62515 UniProt | EBI | MGI Sequence Detail 361 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(24) Phenotypes All phenotypic alleles(4) : Targeted, knock-out(1) Targeted, other(1) Spontaneous(1) Radiation induced(1) Homozygotes for spontaneous, radiation-induced and targeted null mutations exhibit developmental malformations of the inner ear resulting in head-shaking and hearing loss. Associated Human Diseases (1)   Alleles Annotated to Human Diseases (4)   Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(2 from dbSNP Build 128)   Gene Ontology (GO) classifications Process forebrain neuron differentiation, inner ear development... Component nucleus Function DNA binding, sequence-specific DNA binding... All GO classifications(15) Expression Literature Summary: (34 records) Data Summary: Assays (8)    Results (212)    Tissues (137)    Images (17) Theiler Stages: 13,17,19,20,21,22,23,25,28   Assay Type Assays   Results       RNA in situ 6   206       Immunohistochemistry 2   6 cDNA source data(5) External Resources: GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000056854 DoTS DT.101336841, DT.99857103 DFCI TC1603471, TC1606886, TC1660269 NIA Mouse Gene Index U020145, U020146 Entrez Gene 18994 VEGA Gene Model OTTMUSG00000018379 Protein domains InterPro ID Description IPR000327 POU-specific IPR001356 Homeobox IPR012287 Homeodomain-related IPR013847 POU IPR016362 Transcription factor, homeobox/POU Graphical View of Protein Domain Structure Molecular reagents All nucleic(14) Genomic(3) cDNA(7) Primer pair(2) Other(2) Antibodies(1) References (Earliest) J:13741 Phillips RJS et al., "New sex-linked mutant - Bhd" Mouse News Lett 1978;58():43-4 (Latest) J:134489 Trowe MO et al., "Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes." Development 2008 May;135(9):1725-34 All references(56) Other accession IDs MGD-MRK-13084, MGD-MRK-14438, MGD-MRK-1626, MGD-MRK-18721, MGI:98317