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Tcf12 Gene Detail  Symbol Name ID Tcf12 transcription factor 12 MGI:101877 Nomenclature History Synonyms ALF1, HEB, HTF-4, HTF4, ME1, REB Genetic Map Chromosome 9 42.0 cM Detailed Genetic Map ± 1 cM   Mapping data( 8) Sequence Map Chr9:71693560-71959426 bp, - strand (From NCBI annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Tcf12 ± 2 cM) Protein SuperFamily: transcription factor 3 TreeFam: TF321672 Sequences Representative Sequences Length Strain/Species Flank genomic 21406 NCBI Gene Model | MGI Sequence Detail 265867 C57BL/6J ± Kb transcript NM_011544 RefSeq | MGI Sequence Detail 4707 C57BL/6 polypeptide Q61286 UniProt | EBI | MGI Sequence Detail 706 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(40) Phenotypes All phenotypic alleles(3) : Targeted, knock-out(1) Targeted, other(2) Mice homozygous for a targeted null mutation exhibit postnatal lethality within two weeks of birth and a 50% reduction in the number of pro-B cells. Polymorphisms RFLP(1) SNPs within 2kb(1246 from dbSNP Build 128)   Gene Ontology (GO) classifications Process multicellular organismal development, regulation of transcription... Component nucleus, transcription factor complex... Function DNA binding, protein binding... All GO classifications(12) Expression Literature Summary: (15 records) Data Summary: Assays (9)    Results (158)    Tissues (98)    Images (30) Theiler Stages: 2,3,4,5,10,11,12,13,14,16,17,20,21,23,28   Assay Type Assays   Results       RT-PCR 2   17       RNA in situ 6   132       Northern blot 1   9 cDNA source data(26) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000032228 DoTS DT.101249727, DT.101394004, DT.55252504, DT.55257388, DT.55261901, DT.91576903, DT.94224421, DT.99857779 DFCI TC1578733, TC1583480, TC1585952, TC1627947, TC1671446 NIA Mouse Gene Index U031072 Entrez Gene 21406 Gene Traps AJ0492, CD0455, CMHD-GT_265B2-3, IST10605B8HMF1, IST10825H1BBF1    (All 33...) Protein domains InterPro ID Description IPR001092 Basic helix-loop-helix dimerisation region bHLH IPR011598 Helix-loop-helix DNA-binding Graphical View of Protein Domain Structure Molecular reagents All nucleic(32) Genomic(1) cDNA(27) Primer pair(3) Other(1) References (Earliest) J:1499 Nielsen AL et al., "Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloning." Mol Cell Biol 1992 Aug;12(8):3449-59 (Latest) J:136143 Wikstrom I et al., "A role for E2-2 at the DN3 stage of early thymopoiesis." Mol Immunol 2008 Jun;45(11):3302-11 All references(40) Other accession IDs MGD-MRK-18703