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Tead1 Gene Detail  Symbol Name ID Tead1 TEA domain family member 1 MGI:101876 Nomenclature History Synonyms Gtrgeo5, mTEF-1, Tcf13, TEAD-1, TEF-1 Genetic Map Chromosome 7 cytoband F2   Mapping data( 1) Sequence Map Chr7:119823107-120043504 bp, + strand (From NCBI annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; rat    (Mammalian Orthology) Protein SuperFamily: transcriptional enhancer factor TreeFam: TF313443 Sequences Representative Sequences Length Strain/Species Flank genomic 21676 NCBI Gene Model | MGI Sequence Detail 220398 C57BL/6J ± Kb transcript NM_009346 RefSeq | MGI Sequence Detail 2811 - polypeptide P30051 UniProt | EBI | MGI Sequence Detail 426 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(26) Phenotypes All phenotypic alleles(2) : Targeted, knock-out(1) Gene trapped(1) Mice homozygous for disruptions in this gene die between embryonic day 11 and 12.5. Abnormalities were seen in heart development. Polymorphisms SNPs within 2kb(1136 from dbSNP Build 128)   Gene Ontology (GO) classifications Process heart development, positive regulation of transcription from RNA polymerase II promoter... Component nucleus, transcription factor complex... Function DNA binding, protein binding... All GO classifications(12) Expression Literature Summary: (12 records) Data Summary: Assays (8)    Results (74)    Tissues (64)    Images (9) Theiler Stages: 1,2,3,4,5,10,14,15,16,17,21,28   Assay Type Assays   Results       RT-PCR 3   27       RNA in situ 4   37       Northern blot 1   10 cDNA source data(35) External Resources: Allen Brain Atlas  GEO  Other database links Ensembl Gene Model ENSMUSG00000055320 DoTS DT.40149941, DT.489389, DT.94154201, DT.94154214 UniGene 28081 DFCI TC1584118, TC1598824, TC1630385 NIA Mouse Gene Index U008646 Entrez Gene 21676 Gene Traps 3SD021D11, 3SD024A04, 3SD024E05, 3SD030C09, 3SD031F10    (All 436...) Protein domains InterPro ID Description IPR000818 TEA/ATTS IPR016361 Transcriptional enhancer factor Graphical View of Protein Domain Structure Molecular reagents All nucleic(39) cDNA(36) Primer pair(3) References (Earliest) J:48110 Burglin TR, "The TEA domain: a novel, highly conserved DNA-binding motif [letter]" Cell 1991 Jul 12;66(1):11-2 (Latest) J:142508 Ota M et al., "Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling." Development 2008 Dec;135(24):4059-69 All references(22) Other accession IDs MGD-MRK-18702, MGD-MRK-18736