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Thpo Gene Detail  Symbol Name ID Thpo thrombopoietin MGI:101875 Nomenclature History Synonyms Mpllg, myeloproliferative leukemia virus oncogene ligand, TPO, TPO-1, TPO-2, TPO-3, TPO-4 Genetic Map Chromosome 16 13.8 cM Detailed Genetic Map ± 1 cM   Mapping data( 7) Sequence Map Chr16:20725231-20734584 bp, - strand (From VEGA annotation of NCBI Build 37) VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; dog, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Thpo ± 2 cM) Protein SuperFamily: thrombopoietin TreeFam: TF338084 Sequences Representative Sequences Length Strain/Species Flank genomic OTTMUSG00000021017 VEGA Gene Model | MGI Sequence Detail 9354 C57BL/6J ± Kb transcript NM_009379 RefSeq | MGI Sequence Detail 2416 C57BL/6 polypeptide P40226 UniProt | EBI | MGI Sequence Detail 356 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(15) Phenotypes All phenotypic alleles(1) : Targeted, knock-out(1) Mice homozygous for targeted mutations at this locus are unable to produce normal amounts of megakaryocytes and platelets. Polymorphisms RFLP(1) SNPs within 2kb(7 from dbSNP Build 128)   Gene Ontology (GO) classifications Process cell proliferation, myeloid cell differentiation... Component extracellular region, extracellular space... Function cytokine activity, hormone activity... All GO classifications(9) Expression Literature Summary: (5 records) Data Summary: Assays (3)    Results (28)    Tissues (19)    Images (2) Theiler Stages: 9,10,12,14,16,18,21,22,23,26,28   Assay Type Assays   Results       Western blot 1   7       RT-PCR 2   21 cDNA source data(12) External Resources: Allen Brain Atlas  GEO  Other database links Ensembl Gene Model ENSMUSG00000022847 DoTS DT.101140603, DT.40158172 UniGene 3943 DFCI TC1589410, TC1595733 NIA Mouse Gene Index U036894 Entrez Gene 21832 VEGA Gene Model OTTMUSG00000021017 Gene Traps CMHD-GT_302G4-3, OST271215 Protein domains InterPro ID Description IPR001323 Erythropoietin/thrombopoeitin IPR003978 Thrombopoeitin IPR012351 Four-helical cytokine, core Graphical View of Protein Domain Structure Molecular reagents All nucleic(18) Genomic(3) cDNA(12) Primer pair(3) Antibodies(1) References (Earliest) J:18896 Lok S et al., "Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo [see comments]" Nature 1994 Jun 16;369(6481):565-8 (Latest) J:111140 Buza-Vidas N et al., "Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK." Genes Dev 2006 Aug 1;20(15):2018-23 All references(38) Other accession IDs MGD-MRK-16629, MGD-MRK-18701