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F2r Gene Detail  Symbol Name ID F2r coagulation factor II (thrombin) receptor MGI:101802 Nomenclature History Synonyms Cf2r, Par1, thrombin receptor, ThrR Genetic Map Chromosome 13 47.0 cM Detailed Genetic Map ± 1 cM   Mapping data( 10) Sequence Map Chr13:96371744-96388388 bp, - strand (From NCBI annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; dog, domestic; hamster, Chinese; rat    (Mammalian Orthology) Comparative Map (Mouse/Human F2r ± 2 cM) Protein SuperFamily: proteinase-activated receptor TreeFam: TF330775 Sequences Representative Sequences Length Strain/Species Flank genomic 14062 NCBI Gene Model | MGI Sequence Detail 16645 C57BL/6J ± Kb transcript NM_010169 RefSeq | MGI Sequence Detail 3296 - polypeptide P30558 UniProt | EBI | MGI Sequence Detail 430 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(26) Phenotypes All phenotypic alleles(4) : Targeted, knock-out(3) Gene trapped(1) Targeted mutations of this locus result in increased midgestational lethality, with up to ~50% of mutants surviving to adulthood. Gene deficiency does not affect thrombin signaling in mouse platelets but markedly attenuates thrombin signaling in mouse microvascular endothelial cells. Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(107 from dbSNP Build 128)   Gene Ontology (GO) classifications Process blood coagulation, death... Component integral to membrane, membrane... Function G-protein coupled receptor activity, receptor activity... All GO classifications(21) Expression Literature Summary: (6 records) Data Summary: Assays (1)    Results (4)    Tissues (2) Theiler Stages: 28   Assay Type Assays   Results       RT-PCR 1   4 cDNA source data(7) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links Ensembl Gene Model ENSMUSG00000048376 DoTS DT.489079 DFCI TC1572371 NIA Mouse Gene Index U035056 Entrez Gene 14062 Gene Traps OST127345, OST43164, OST60521 Protein domains InterPro ID Description IPR000276 GPCR, rhodopsin-like IPR000935 Thrombin receptor IPR003912 Protease-activated receptor IPR017452 GPCR, rhodopsin-like superfamily Graphical View of Protein Domain Structure Molecular reagents All nucleic(13) Genomic(4) cDNA(7) Primer pair(2) References (Earliest) J:16414 Soifer SJ et al., "Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development." Am J Pathol 1994 Jan;144(1):60-9 (Latest) J:138924 Versteeg HH et al., "Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice." Cancer Res 2008 Sep 1;68(17):7219-27 All references(58) Other accession IDs MGD-MRK-18613, MGI:2145260