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Cdk5 Gene Detail  Symbol Name ID Cdk5 cyclin-dependent kinase 5 MGI:101765 Nomenclature History Synonyms Crk6 Genetic Map Chromosome 5 12.0 cM, cytoband A3-B1 Detailed Genetic Map ± 1 cM   Mapping data( 5) Sequence Map Chr5:23924068-23929348 bp, - strand (From Ensembl annotation of NCBI Build 37) Ensembl ContigView | UCSC Browser | NCBI Map Viewer Mouse Genome Browser Mammalian homology human; chimpanzee; dog, domestic; rat    (Mammalian Orthology) Comparative Map (Mouse/Human Cdk5 ± 2 cM) Protein SuperFamily: kinase-related transforming protein TreeFam: TF101023 Sequences Representative Sequences Length Strain/Species Flank genomic ENSMUSG00000028969 Ensembl Gene Model | MGI Sequence Detail 5281 C57BL/6J ± Kb transcript NM_007668 RefSeq | MGI Sequence Detail 2058 C57BL/6 polypeptide P49615 UniProt | EBI | MGI Sequence Detail 292 Not Applicable For the selected sequences download in FASTA format forward to MouseBLAST All sequences(24) Phenotypes All phenotypic alleles(4) : Targeted, knock-out(2) Targeted, other(2) Homozygous mutation of this gene results in perinatal lethality and abnormalities of the cerebellum and nervous system. Mutant mice are cyanotic, hypoactive, exhibit shallow breathing, and fail to suckle. Polymorphisms RFLP(2) SNPs within 2kb(22 from dbSNP Build 128)   Gene Ontology (GO) classifications Process apoptosis, associative learning... Component axon, cell projection... Function acetylcholine receptor activator activity, ATP binding... All GO classifications(74) Expression Literature Summary: (28 records) Data Summary: Assays (8)    Results (83)    Tissues (58)    Images (3) Theiler Stages: 23,24,25,26,28   Assay Type Assays   Results       Western blot 6   29       RT-PCR 1   46       RNA in situ 1   8 cDNA source data(43) External Resources: Allen Brain Atlas  GENSAT  GEO  Other database links EC 2.7.11.22 Ensembl Gene Model ENSMUSG00000028969 DoTS DT.110653264, DT.99862847 UniGene 298798 DFCI TC1575084 NIA Mouse Gene Index U025994 Entrez Gene 12568 Protein domains InterPro ID Description IPR000719 Protein kinase, core IPR002290 Serine/threonine protein kinase IPR008271 Serine/threonine protein kinase, active site IPR017441 Protein kinase ATP binding, conserved site IPR017442 Serine/threonine protein kinase-related Graphical View of Protein Domain Structure Molecular reagents All nucleic(51) Genomic(6) cDNA(43) Primer pair(1) Other(1) Antibodies(2) References (Earliest) J:36350 Eiden LE et al., "A nomenclature proposal for the chromogranin/secretogranin proteins." Neuroscience 1987 Jun;21(3):1019-21 (Latest) J:142213 Lagace DC et al., "Cdk5 is essential for adult hippocampal neurogenesis." Proc Natl Acad Sci U S A 2008 Nov 25;105(47):18567-71 All references(90) Other accession IDs MGD-MRK-18571, MGD-MRK-2150, MGI:2141132, MGI:88507